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Carbon-14 labelling of FCE 24578, an immunomodulating agent

✍ Scribed by Patrizia Angiuli; Gian Piero Vicario

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
251 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two syntheses of radiocarbon labelled FCE 24578, namely 2‐cyano‐3‐(1,4‐dihydro‐1‐phenyl‐[1]‐benzothiopyrano[4,3‐c]pyrazol‐3‐yl)‐3‐oxo‐N‐phenylpropanamide, are reported. The former gave, employing [1‐^14^C]acetonitrile as labelled starting material and with an overall radiochemical yield of 39%, [cyano‐^14^C]FCE 24578, 97% radiochemically pure and with a specific radioactivity of 299 MBq/mmol.

The latter was carried out with [ring‐U‐^14^C]benzoic acid to give [phenyl‐U‐^14^C]FCE 24578, 96% radiochemically pure, with specific radioactivity of 400 MBq/mmol in an overall radiochemical yield of 40%.

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