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Carbon-13 NMR studies of naturally occurring maytansinoids

✍ Scribed by William A. Wallace; Albert T. Sneden

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
409 KB
Volume
19
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The ^13^C NMR spectra of the antileukemic ansa macrolide maytansine and eight naturally occurring homologues were recorded. Signals were assigned to specific carbon atoms of the ansa macrolide ring and C‐3 ester side chain using data from off‐resonance decoupling, single frequency decoupling, and 180°–τ–907° double pulse experiments. The assignment of each carbon is discussed for maytansine and tabulated for the other eight maytansinoids.

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