Carbamazepine and its 10,11-epoxide in children and adults with epilepsy
✍ Scribed by S. Pynnönen; M. Sillanpää; H. Frey; E. Iisalo
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 427 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0031-6970
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📜 SIMILAR VOLUMES
The in vivo serum protein binding characteristics of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) were assessed in sera from 23 paediatric patients on CBZ monotherapy. We assumed that CBZ and CBZ-E binding to serum proteins comprised specific binding sites on alpha 1-acid glycoprotein
## Carbamazepine (Tegretol", CBZ) is an anticonvulsant drug that is very effective in the treatment of tonic-clonic seizures and is gaining acceptance as a treatment for various psychiatric disorders. The drug is embryotoxic in rodents and has been reported to produce neural tube defects in approx