Capillary zone electrophoresis of peptides: prediction of the electrophoretic mobility and resolution
โ Scribed by M. Castagnola; L. Cassiano; I. Messana; G. Nocca; R. Rabino; D.V. Rossetti; B. Giardina
- Publisher
- Elsevier Science
- Year
- 1994
- Weight
- 883 KB
- Volume
- 656
- Category
- Article
- ISSN
- 0378-4347
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Capillary zone electrophoresis can be used to determine mobilities and diffusion coefficients for analytes. Mobilities are determined from measurements of migration times. Correction for electroosmotic flow must be made by measuring the flow magnitude using an uncharged marker substance. Diffusion c
It was found that unlike the electroosmotic flow, the electrophoretic mobilities of small peptides in capillary zone electrophoresis (CZE) were invariant over the buffer concentration range studied. Migration of these peptides in CZE is a electroosmotic-governed process. The quantitative linear rela
## Abstract In a drug development program improved speed of the development phase is constantly being explored. But much effort and time is usually expended in finding suitable methods for pharmaceutical and biomedical analyses. In contrast, a mathematical model has been presented here to correlate