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Candida Rugosa Lipase Catalyzed Kinetic Resolution of β-Hydroxy-β-arylpropionates and δ-Hydroxy-δ-aryl-β-oxo-pentanoates.

✍ Scribed by Chengfu Xu; Chengye Yuan


Publisher
John Wiley and Sons
Year
2005
Weight
41 KB
Volume
36
Category
Article
ISSN
0931-7597

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Chemoenzymatic dynamic kinetic resolution of b-hydroxy nitriles 1 has been carried out using Candida antarctica lipase B and a ruthenium catalyst. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates 2 in good yield and high ena