## Abstract Lithiation of diethyl methylphosphonate (**1**) with __n__‐butyllithium followed by carbonation with [^14^C]carbon dioxide and esterification with diazoethane afforded high specific activity triethyl [1‐^14^C]phosphonoacetate (**4**) in 62% yield.
C14 Polyacetylenes from Brazilian lobelioideae
✍ Scribed by Aderbal F. Magalhães; Durval Marcos Vieira; Eva G. Magalha˜es; George J. Shepherd
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 295 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0031-9422
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The synthesis and purification of 14C-cotinine is reported. 14C-nicotine is converted into 14C-dibromocotinine. Debromination of the latter results in 14C-cotinine which is purified by high performance liquid chromatography. The total radioactive yield of the synthesis is 44.8 %. Starting from 5
## Abstract A convenient synthesis with analytical monitoring of ^14^C‐cotinine is reported. ^14^C‐Nicotine was converted into ^14^C‐dibromocotinine hydrobromide perbromide. Debromination, achieved by using Zn dust/acetic acid, resulted in high yields (71%) of ^14^C‐cotinine.
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