BRCA2 mutations in primary breast and ovarian cancers
โ Scribed by Lancaster, Johnathan M.; Wooster, Richard; Mangion, Jonathon; Phelan, Catherine M.; Cochran, Charles; Gumbs, Curtis; Seal, Sheila; Barfoot, Rita; Collins, Nadine; Bignell, Graham; Patel, Sandeep; Hamoudi, Rifat; Larsson, Catharina; Wiseman, Roger W.; Berchuck, Andrew; Iglehart, J. Dirk; Marks, Jeffrey R.; Ashworth, Alan; Stratton, Michael R.; Futreal, P. Andrew
- Book ID
- 118676006
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 378 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1061-4036
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๐ SIMILAR VOLUMES
We report on the screening of the entire BRCA1/BRCA2 coding sequence by SSCP, PTT, and direct sequencing in 68 Italian families with recurrent breast or ovarian cancer. For each investigated proband, the probability of being carrier of a BRCA1/BRCA2 mutation was evaluated using the BRCAPRO software.
## Abstract Among Asian countries, Pakistan has the highest rates of breast and ovarian cancer. To assess the contribution of the __BRCA1__ and __BRCA2__ germ line mutations to these high rates, we conducted the first study of 176 Pakistani breast and ovarian cancer patients, selected on family his