Germline BRCA1–2 Mutations in Non-Ashkenazi Families with Double Primary Breast and Ovarian Cancer
✍ Scribed by John O. Schorge; Neda M. Mahoney; David S. Miller; Robert L. Coleman; Carolyn Y. Muller; David M. Euhus; Gail E. Tomlinson
- Book ID
- 112248717
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 48 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0090-8258
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Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio