BRCA1- and BRCA2-related mutations: therapeutic implications in ovarian cancer
β Scribed by Pothuri, B.
- Book ID
- 121681786
- Publisher
- Oxford University Press
- Year
- 2013
- Tongue
- English
- Weight
- 121 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0923-7534
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A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide association study (GWAS) identified six alleles associated with risk of ovarian cancer for women in the general population. We evaluated four of these loci as potential modifiers of