## Abstract Age‐adjusted incidence rates of breast cancer vary more than 10‐fold worldwide, with the highest rates reported in North America and Europe. The highest breast cancer incidence rates in Southeast Asia have been reported for the Manila Cancer Registry in the Philippines, with an age‐stan
BRCA1 and BRCA2 mutations among ovarian cancer patients from Colombia
✍ Scribed by Alexandra Ortiz Rodríguez; Marcia Llacuachaqui; Gonzalo Guevara Pardo; Robert Royer; Garrett Larson; Jeffrey N. Weitzel; Steven A. Narod
- Book ID
- 113963500
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 620 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0090-8258
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We report on the screening of the entire BRCA1/BRCA2 coding sequence by SSCP, PTT, and direct sequencing in 68 Italian families with recurrent breast or ovarian cancer. For each investigated proband, the probability of being carrier of a BRCA1/BRCA2 mutation was evaluated using the BRCAPRO software.
We have investigated the impact of BRACA1 and BRACA2 mutations that were frequently identified among Hungarian high-risk breast-ovarian cancer families (Ramus et al., 1997b, AJHG), on the development of breast and ovarian cancer in the general Hungarian population. The prevalence of 3 BRCA1 mutation