Brain tryptamine in rats by a new gas chromatography-mass fragmentographic method
β Scribed by J.J. Warsh; D.D. Godse; H.C. Stancer; P.W. Chan; D.V. Coscina
- Book ID
- 115766618
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 604 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0006-2944
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π SIMILAR VOLUMES
A capillary column gas chromatographic mass spectrometric method, involving the use of a deuterated analogue as internal standard, was developed and used to identify and quantify tryptamine in the rat brain. The mean level of tryptamine in rat whole brain was 0.54 pmolg-l.
The development of an analytical method for the determination of brain tryptamine using capillary gas chromatography mass spectrometry (selected ion monitoring) is presented. The method involves solvent extraction of brain homogenates and further derivatization (pentafluoropropionyl derivatives) of