## Abstract ## BACKGROUND. Numerous studies have investigated the clinical significance of __BRAF__ mutation in papillary thyroid carcinoma (PTC). However, there have been conflicting data on the usefulness of __BRAF__ mutation as a prognostic marker of PTC. To address this controversy, the freque
BRAF mutations in papillary carcinomas of the thyroid
β Scribed by Fukushima, Toshihiko; Suzuki, Shinichi; Mashiko, Miyuki; Ohtake, Tohru; Endo, Yoshiyuki; Takebayashi, Yuji; Sekikawa, Koji; Hagiwara, Koichi; Takenoshita, Seiichi
- Book ID
- 110067830
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 128 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract In papillary thyroid carcinogenesis, the constitutively activated mitogenβactivated protein (MAP) kinase signaling pathway caused by a genetic alteration such as __RET__/__PTC__ rearrangement or mutation of __RAS__ and __BRAF__ genes, is thought to be a major early event. Among these, t
## Abstract ## Background. An activating point mutation of the __BRAF__ oncogene results in a V600E amino acid missense mutation found in a majority of papillary thyroid carcinomas (PTC). ## Methods. In this study, 28 matched tumor and serum samples obtained from patients with both benign and ma