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Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAFV599Ins)

✍ Scribed by Claudio Carta; Sonia Moretti; Lucia Passeri; Flavia Barbi; Nicola Avenia; Antonio Cavaliere; Massimo Monacelli; Antonio Macchiarulo; Fausto Santeusanio; Marco Tartaglia; Efisio Puxeddu

Book ID: 108703301
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 150 KB
Volume: 64
Category: Article
ISSN: 0300-0664
DOI: 10.1111/j.1365-2265.2005.02401.x

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## Abstract ## BACKGROUND: Although several studies undoubtedly demonstrated that __BRAF__ mutation is an important genetic event in the pathogenesis of papillary thyroid carcinoma (PTC), its prognostic significance and correlation with less differentiated states remains unclear. It has been sugge