𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid : A meta-analysis

✍ Scribed by Ju-Han Lee; Eung-Seok Lee; Young-Sik Kim

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
699 KB
Volume
110
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BACKGROUND.

Numerous studies have investigated the clinical significance of BRAF mutation in papillary thyroid carcinoma (PTC). However, there have been conflicting data on the usefulness of BRAF mutation as a prognostic marker of PTC. To address this controversy, the frequency of the BRAF mutation and the associations between BRAF mutation and clinicopathologic parameters in PTC were evaluated by meta‐analysis.

METHODS.

The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of outcome parameters were estimated by odds ratio or weighted mean difference.

RESULTS.

The current meta‐analysis included 12 studies with a total of 1168 patients. The frequency of the BRAF mutation was 49%. The BRAF mutation was associated with histologic subtype, the presence of extrathyroidal extension, and higher clinical stage, but not with age, sex, race, or tumor size.

CONCLUSIONS.

The effect of the BRAF mutation on the poor prognosis of PTC patients was evident from the current meta‐analysis. The detection of the BRAF mutation may be used as an important prognostic marker of patients with PTC. Cancer 2007. Β© 2007 American Cancer Society.

πŸ“œ SIMILAR VOLUMES

The presence of BRAF point mutation in a
The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose
✍ Keiko Takahashi; Hidetaka Eguchi; Koji Arihiro; Reiko Ito; Kojiro Koyama; Midori πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 138 KB πŸ‘ 1 views

## Abstract In papillary thyroid carcinogenesis, the constitutively activated mitogen‐activated protein (MAP) kinase signaling pathway caused by a genetic alteration such as __RET__/__PTC__ rearrangement or mutation of __RAS__ and __BRAF__ genes, is thought to be a major early event. Among these, t

BRAFV600E mutation and p27kip1 expressio
BRAFV600E mutation and p27kip1 expression in papillary carcinomas of the thyroid ≀1 cm and their paired lymph node metastases
✍ Vito Rodolico; Daniela Cabibi; Giuseppe Pizzolanti; Pierina Richiusa; Nicola Geb πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 264 KB πŸ‘ 1 views

## Abstract ## BACKGROUND. __BRAF^V600E^__ mutation and p27^kip1^ expression have been introduced as novel indicators that may predict prognosis in different tumors, as well as in papillary thyroid carcinomas. ## METHODS. Tissue samples from 214 consecutive patients who underwent total or near‐t

High prevalence of BRAF mutation in a Br
High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas : Correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes
✍ Gisele Oler; Janete M. Cerutti πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 166 KB πŸ‘ 1 views

## Abstract ## BACKGROUND: Although several studies undoubtedly demonstrated that __BRAF__ mutation is an important genetic event in the pathogenesis of papillary thyroid carcinoma (PTC), its prognostic significance and correlation with less differentiated states remains unclear. It has been sugge