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BRAF Mutations in Aberrant Crypt Foci and Hyperplastic Polyposis

โœ Scribed by Robyn Beach; Annie On-On Chan; Tsung-Teh Wu; Jill A. White; Jeffrey S. Morris; Simon Lunagomez; Russell R. Broaddus; Jean-Pierre J. Issa; Stanley R. Hamilton; Asif Rashid

Book ID
117021317
Publisher
American Society for Investigative Pathology
Year
2005
Tongue
English
Weight
417 KB
Volume
166
Category
Article
ISSN
0002-9440

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## Background: The authors examined somatic mutations of the adenomatous polyposis coli (apc) gene in 84 human aberrant crypt foci (acf) to determine whether apc gene mutations were involved in the histologic progression of acf. ## Methods: Mutation cluster regions of the apc gene were subjected