Aberrant crypt foci (ACF) are putative precursor lesions of colon cancer, recently identified on the methylene blue-stained mucosal surface of human colon. No mutations in K-vas or p53 genes were found by non-radioactive single-strand conformation polymorphism analysis in 14 ACF collected from five
โฆ LIBER โฆ
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients
โ Scribed by N. Shivapurkar; L. Huang; B. Ruggeri; P.A. Swalsky; A. Bakker; S. Finkelstein; A. Frost; S. Silverberg
- Book ID
- 117468920
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 678 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0304-3835
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Mutations in the Ki-ras oncogene and the p53 tumor suppressor gene are known to occur at high frequencies in human colon cancers. We measured the frequency of mutations in these two genes in colon adenocarcinomas obtained from a widely used experimental model of human colon carcinogenesis: F344 rats