Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci
β Scribed by Liang Peng; Jingjing Hu; Shujun Li; Zhongqiu Wang; Bingqing Xia; Bo Jiang; Bingsheng Li; Yu Zhang; Jing Wang; Xinying Wang
- Book ID
- 115556570
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- French
- Weight
- 638 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0020-7136
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## Abstract AKR/J mice are resistant to the tumorigenic properties of the colon carcinogen, azoxymethane (AOM). Following AOM exposure, limited numbers of preneoplastic lesions, referred to as aberrant crypt foci (ACF), are formed in the colon, and their progression to tumors rarely occurs. To dete
## Abstract Aberrant methylation of CpG islands is a common alteration in human colon cancer. Methylation of only a limited number of loci has been studied in aberrant crypt foci (ACF), the earliest identified premalignant lesions in the colon, and in only a limited number of lesions from the same