𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Boronic ester as a linker system for solid phase synthesis

✍ Scribed by Bertrand Carboni; Christelle Pourbaix; François Carreaux; Hervé Deleuze; Bernard Maillard

Book ID
104262427
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
303 KB
Volume
40
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A method for attaching boronic acids to a macroporous polymer-supported 1,3-diol was developed. Chemical modifications of some polymer-bound arylboronic acids were realised using various reaction conditions. Transesterification gave new boronates in high purity while oxidative cleavage directly led to phenols.

📜 SIMILAR VOLUMES

Solid-phase synthesis of serglycin glyco
Solid-phase synthesis of serglycin glycopeptides on a new allyl ester linker
✍ Yuko Nakahara; Sumie Ando; Masaki Itakura; Naomi Kumabe; Hironobu Hojo; Yukishig 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 172 KB

t-Butyl 6-bromo-(E)-4-hexenoate was used as a handle for the solid-phase synthesis of glycopeptides. The handle was ®rst conjugated with Fmoc amino acids to form the allyl esters, which were then attached to the Sieber amide resin via acidic cleavage of the t-butyl esters followed by activation of t

A linker for amidines in solid phase syn
A linker for amidines in solid phase synthesis
✍ Patrick Roussel; Mark Bradley; Ian Matthews; Peter Kane 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 220 KB

A range of linkers for the important amidine pharmacophore, cleavable using acid or light have been developed for use in library synthesis. The utility of these linkers is demonstrated by the solid phase synthesis of the Novartis (ex-Ciha) phase II compound CGS-25019C.