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A linker for amidines in solid phase synthesis

โœ Scribed by Patrick Roussel; Mark Bradley; Ian Matthews; Peter Kane

Book ID
104257371
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
220 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A range of linkers for the important amidine pharmacophore, cleavable using acid or light have been developed for use in library synthesis. The utility of these linkers is demonstrated by the solid phase synthesis of the Novartis (ex-Ciha) phase II compound CGS-25019C.

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