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Boron-11 NMR of borocaptate: Relaxation and in vivo detection in melanoma-bearing mice

✍ Scribed by Peter Bendel; Anatol Frantz; Judith Zilberstein; George W. Kabalka; Yoram Salomon

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
818 KB
Volume
39
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Longitudinal and transverse relaxation rates for the ^11^B resonances in sodium borocaptate (BSH) at varying concentrations were measured in undiluted horse serum in a 4.7 Tesla field. The results could be fit by a model that assumes fast exchange of the BSH molecule between a free and a bound state, using values of 0.77 ± 0.7 MHz for the ^11^B quadrupole coupling constant and (6.3 ± 0.9) × 10^−9^ s for the rotational correlation time in the bound state. These results were used as a basis for assessing the requirements and limitations of quantitative determination of BSH concentrations in vivo, using ^11^B NMR. Surface coil ^11^B NMR spectroscopy was performed on a total of 14 mice injected with BSH. Some of the animals (n = 9) had implanted M2R melanoma tumors grown to various sizes in the rear thigh, in which case the surface coil was placed against the tumor, whereas for the other animals (without tumor), the coil was placed against the rear thigh muscle. NMR spectra were acquired under fully relaxed conditions. The spectra were quantitated by peak integration; apparent absolute BSH concentrations were derived by comparison with spectra from a phantom with known BSH concentration, using extrapolation of the time‐domain data to zero preacquisition delay. The results indicate significantly higher ^11^B BSH signal intensities in tumors, compared with muscle tissue, whereas the uptake and clearance kinetics were similar.

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