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Synthesis and characterization of 7-(CH3)3N-4- {2,4-(NO2)2C6H3S}-nido-7-CB10H11 and its Biodistribution in C57B16 Mice Bearing B16 Melanoma

✍ Scribed by John H. Morris; Gavin S. Peters; Elena Koldaeva; Raisa Spryshkova; Gergy Borisov

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 233 KB
Volume: 9
Category: Article
ISSN: 0268-2605
DOI: 10.1002/aoc.590090405

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

7‐(CH~3~)~3~N‐4‐{2,4‐(NO~2~)~2~C~6~H~3~S}‐nido‐7‐CB~10~H~11~ has been synthesized through a Friedel‐Crafts substitution reaction on 7‐(CH~3~)3N‐nido‐7‐ CB~10~H~12~. A biodistribution study in mice with implanted B16 melanoma indicates that the compound locates in neoplastic tissue at concentrations which suggest that its use in ^10^B neutron capture therapy may be feasible.

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