𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In Vivo Electrochemical Detection of Nitroglycerin-Derived Nitric Oxide in Tumor-Bearing Mice

✍ Scribed by Sophie Griveau; Johanne Seguin; Daniel Scherman; Guy G. Chabot; Fethi Bedioui

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
220 KB
Volume
21
Category
Article
ISSN
1040-0397

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The ability of an inserted electrode to detect in vivo NO in tumor was achieved by using a chemically modified Pt/Ir electrode as NO‐sensor and nitroglycerin NTG as NO donor. Enzymatically induced release of NO from NTG was tracked in the tumor, upon intra peritoneal injection of NTG. This approach allowed in vivo monitoring of the bioavailability of NO and could be applied to the in vivo study of candidate anticancer drugs acting on the NO pathways.

📜 SIMILAR VOLUMES

Induction of nitric oxide production in
Induction of nitric oxide production in infiltrating leukocytes following in vivo irradiation of tumor-bearing mice
✍ Yoram Vodovotz; Deborah Coffin; Anne Marie DeLuca; Leslie McKinney; John A. Cook 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB 👁 2 views

Nitric oxide (NO) has been implicated both in regression and progression of tumors due to its production by both tumor cells and infiltrating leukocytes. Ionizing radiation causes the regression of tumors, and can augment the production of NO by macrophages in vitro. We examined the cellular and sys

Electrochemical Detection of Nitric Oxid
Electrochemical Detection of Nitric Oxide in Biological Systems
✍ Andrew J. Gow; Stephen R. Thom; Clifford Brass; Harry Ischiropoulos 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 96 KB

Nitric oxide is a key regulator of diverse physiological processes that include vasoregulation, platelet and neutrophil adherence, and immune defense. The detection and quantification of nitric oxide has been accomplishd by a variety of methodologies. In this paper we desribe methodologies to detect

Macrophage-derived nitric oxide induces
Macrophage-derived nitric oxide induces apoptosis of rat hepatoma cells in vivo
✍ Manabu Nishikawa; Eisuke F. Sato; Tetsuo Kuroki; Kozo Utsumi; Masayasu Inoue 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 843 KB

Although nitric oxide (NO) has been postulated to play important roles in host defense mechanisms against tumor cells, a direct evidence supporting this hypothesis is lacking. To obtain molecular insights into the antitumor action of NO, its metabolism and effect on ascites hepatoma (AH-130) cells w

Decreased macrophage-mediated cytotoxici
Decreased macrophage-mediated cytotoxicity in mammary-tumor-bearing mice is related to alteration of nitric-oxide production and/or release
✍ Eduardo M. Sotomayor; Michael R. Dinapoli; Cesar Calderón; Arthur Colsky; Yang-X 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 866 KB

## Abstract Peritoneal‐exudate macrophages (PEM) from mammarytumor‐bearing mice have impaired cytotoxic activity against syngeneic and allogeneic tumor targets. The ability of PEM from normal and tumor‐bearing mice to bind tumor targets was found to be similar in the presence or the absence of surr

Determination and characterization of ni
Determination and characterization of nitric oxide generation in mice by in vivo l-band EPR spectroscopy
✍ Hirotada Fujii; Janusz Koscielniak; Lawrence J. Berliner 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 423 KB

## Abstract The authors have shown direct, real‐time, __in vivo__ measurement of nitric oxide (NO) in mice by using the water soluble metal chelator complex, __N__‐methyl‐D‐glucamine dithiocarbamate (MGD), and Fe(II) as monitored by EPR at L‐band. The three‐line EPR spectrum from the product [(MGD)