In Vivo detection of a boron-neutron-capture agent in melanoma by proton observed 1H - 10B double resonance

✍ Scribed by Peter Bendel; Judith Zilberstein; Yoram Salomon

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 487 KB
• Volume: 32
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910320204

✦ Synopsis

Abstract

The Cesium salt of BSSB (Cs~4~B~24~H~22~S~2~), a common boron‐neutron‐capture‐therapy (BNCT) agent, was injected into M2R mouse melanoma xenografts, and detected in vivo by ^1^H‐observed, ^10^B‐edited NMR spectroscopy. The technique of spin‐echo difference spectroscopy, in which a proton spin‐echo is detected following the alternating presence and absence of a ^10^B 180° pulse was used. This method provides much higher sensitivity than direct ^10^B NMR detection, and should thus be suitable for in vivo detection in patients about to undergo BNCT treatment, where the infused agents are 95% isotopically enriched in ^10^B.