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Bone marrow studies in patients treated with 4 amino-pteroylglutamic acid, 4 amino N10 methyl pteroylglutamic acid and 4 amino-pteroylaspartic acid

✍ Scribed by J.B. Thiersch


Book ID
115672795
Publisher
Elsevier Science
Year
1949
Tongue
English
Weight
113 KB
Volume
7
Category
Article
ISSN
1555-7162

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first reported the palliative effects of 4-amino-pteroylglutamic acid in acute leukemia of children. Burchenal and associates2 observed that this compound and its "0-methyl analogue possessed the ability to prolong survival time of mice with a rather acute strain (Ak 4) of transplanted leukemia. The