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The pharmacological and biochemical activity of 4-amino-4-deoxy-10-methyl-pteroylaspartic acid

✍ Scribed by J.A.R. Mead; N.H. Greenberg; A.W. Schrecker; D.R. Seeger; A.S. Tomcufcik


Book ID
115768849
Publisher
Elsevier Science
Year
1965
Tongue
English
Weight
818 KB
Volume
14
Category
Article
ISSN
0006-2952

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Preparation of analogs of dl-tetrahydrom
✍ J.A. Blair; K.J. Saunders πŸ“‚ Article πŸ“… 1971 πŸ› Elsevier Science 🌐 English βš– 238 KB

## 5-Alkyl derivatives of dl-tetrahydromethotrexate have been prepared by reduction of methotrexate by sodium borohydride followed by reductive condensation with aldehyde and sodium borohydride and formation of the calcium salt (l-3). ## Methods Chemicals were obtained as follows: methotrexate,