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Toxicity and Anti-leukæmic Effectiveness, in Mice, of 4-Amino-4-deoxy-N10-methyl-5,6,7,8-tetrahydropteroylglutamic Acid (Tetrahydroamethopterin)

✍ Scribed by MEAD, J. A. R.; VENDITTI, J. M.; SCHRECKER, A. W.; GOLDIN, A.; KISLIUK, R. L.

Book ID
109614496
Publisher
Nature Publishing Group
Year
1961
Tongue
English
Weight
311 KB
Volume
189
Category
Article
ISSN
0028-0836

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Preparation of analogs of dl-tetrahydrom
Preparation of analogs of dl-tetrahydromethotrexate (4-amino-4-deoxy-N10-methyl-dl-5,6,7,8-tetrahydropterol-l-monoglutamic acid)
✍ J.A. Blair; K.J. Saunders 📂 Article 📅 1971 🏛 Elsevier Science 🌐 English ⚖ 238 KB

## 5-Alkyl derivatives of dl-tetrahydromethotrexate have been prepared by reduction of methotrexate by sodium borohydride followed by reductive condensation with aldehyde and sodium borohydride and formation of the calcium salt (l-3). ## Methods Chemicals were obtained as follows: methotrexate,