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Bone marrow chimerism and transplantation tolerance

โœ Scribed by Boris Nikolic; Megan Sykes


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
776 KB
Volume
9
Category
Article
ISSN
0952-7915

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โœฆ Synopsis


Bone marrow chimerism and transplantation tolerance


๐Ÿ“œ SIMILAR VOLUMES


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Composite tissue allotransplantation holds a great potential for providing increased knowledge of anatomy and microsurgical experience for life-enhancing reconstructions. Many transplant cases around the world have made this a clinical reality at the present time. Composite tissue allotransplants co

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Background: Animals reconstituted with allogeneic whole bone marrow (WBM) are often tolerant of donor-specific solid organ grafts. Clinical application of bone marrow transplantation in solid organ transplantation has been limited, however, principally by graft-versus-host disease. We previously dem

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Composite tissue allografts (CTAs) are currently accepted in the clinic; however, long-term immunosuppression is still needed for allograft survival. The presence of donor-specific chimerism may induce tolerance. Thirty-six vascularized bone marrow transplantation (VBMT) allotransplantation were per