𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chimerism induction in vascularized bone marrow transplants augmented with bone marrow cells

✍ Scribed by Emrah Arslan; Aleksandra Klimczak; Maria Siemionow

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
499 KB
Volume
27
Category
Article
ISSN
0738-1085

No coin nor oath required. For personal study only.

✦ Synopsis

Composite tissue allografts (CTAs) are currently accepted in the clinic; however, long-term immunosuppression is still needed for allograft survival. The presence of donor-specific chimerism may induce tolerance. Thirty-six vascularized bone marrow transplantation (VBMT) allotransplantation were performed across MHC barrier under short-term protocol of 7-day ab-TCRmAb and Cyclosporin A therapy to determine the efficacy of VBMT alone and VBMT augmented with donor bone marrow transplantation (BMT) in chimerism induction. Flow cytometry analysis revealed that VBMT supported with donor BMT directly into the bone resulted in chimerism augmentation and maintenance compared to VBMT. In vivo and in vitro tolerance testing showed prolonged survival of donor skin graft up to 35 days and moderate reactivity in MLR assay that suggests only tolerance induction. Transplantation of vascularized bone without chronic immunosuppression provides a substantial source of bone marrow cells, leading to the development of stable donor-specific chimerism. V

πŸ“œ SIMILAR VOLUMES

Chimerism and bone marrow based therapie
Chimerism and bone marrow based therapies in transplantation
✍ Maria Siemionow; Serdar Nasir πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 155 KB

Composite tissue allotransplantation holds a great potential for providing increased knowledge of anatomy and microsurgical experience for life-enhancing reconstructions. Many transplant cases around the world have made this a clinical reality at the present time. Composite tissue allotransplants co

Bone marrow augmentation in solid organ
Bone marrow augmentation in solid organ transplantation–any conclusions?
✍ John J. Fung πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 236 KB

defect. In the meantime, pediatric gastroenterologists row infusion after orthotopic liver transplantation. welcome the continued efforts at shedding light into Lancet 1994; 263-265. the black box of childhood cholestatic liver disease.