Bone bonding mechanism of ?-tricalcium phosphate

✍ Scribed by Kotani, S. ;Fujita, Y. ;Kitsugi, T. ;Nakamura, T. ;Yamamuro, T. ;Ohtsuki, C. ;Kokubo, T.

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 791 KB
• Volume: 25
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820251010

✦ Synopsis

It has been proposed that the formation of a surface apatite layer in vivo on surface active ceramics is an essential condition for chemical bonding between ceramics and bone tissue. To clarify the difference in bone-bonding mechanisms between surface active ceramics and bioresorbable ceramics, two experiments were performed using plates of dense p-tricalcium phosphate (p-TCP). First, plates of p-TCP were implanted subcutaneously in rats for 8 weeks. Surface change due to bioresorption was observed with scanning electron microscopy. Formation of the apatite layer on the surface was investigated using thin-film x-ray diffraction and Fourier transform infrared reflection spectroscopy. Second, plates of p-TCP were implanted in tibiae of rabbits for 8 and 25 weeks and subjected to the detaching test to measure bone-bonding strength. 6-TCP bonded strongly to bone. Undecalcified sections of the interface of bone and p-TCP were examined with SEM-EPMA. However, by physicochemical methods, no formation of surface apatite layer was observed. These results suggest that p-TCP bonds to bone through microanchoring between bone and rough surface of resorbed p-TCP.