Novel tricalcium silicate/monocalcium phosphate monohydrate composite bone cement

✍ Scribed by Zhiguang Huan; Jiang Chang

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 372 KB
• Volume: 82B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.30740

✦ Synopsis

Abstract

In this paper, we obtained a novel bone cement composed of tricalcium silicate (Ca~3~SiO~5~; C~3~S) and monocalcium phosphate monohydrate (MCPM). The weight ratio of MCPM in the cement is 0, 10, 20, and 30%. The initial setting time was dramatically reduced from 90 min to 30 min as the content of MCPM reached 20%. The workable paste with a liquid/powder (L/P) ratio of 0.8 mL/g could be injected for 2–20 min (nozzle diameter 2.0 mm). The pH variation of the composite cement in simulated body environment was obviously lowered. The compressive strength of the composite cement after setting for 4–28 days was slightly lower than that of the tricalcium silicate paste. The in vitro bioactivity was investigated by soaking in simulated body fluid for 7 days. The result showed that the novel bone cement had good bioactivity and could degrade in tris‐(hydroxymethyl)‐aminomethane‐hydrochloric‐acid (Tris‐HCl) solution. Our result indicated that the Ca~3~SiO~5~/MCPM paste had good hydraulic properties, bioactivity, and degradability. The novel bone cement could be a potential candidate as bone substitute. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007