Novel bioactive composite bone cements based on the β-tricalcium phosphate–monocalcium phosphate monohydrate composite cement system

✍ Scribed by Zhiguang Huan; Jiang Chang

• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 688 KB
• Volume: 5
• Category: Article
• ISSN: 1742-7061
• DOI: 10.1016/j.actbio.2008.10.006

✦ Synopsis

Bioactive composite bone cements were obtained by incorporation of tricalcium silicate (Ca 3 SiO 5 , C 3 S) into a brushite bone cement composed of b-tricalcium phosphate [b-Ca 3 (PO 4 ) 2 , b-TCP] and monocalcium phosphate monohydrate [Ca(H 2 PO 4 ) 2 ÁH 2 O, MCPM], and the properties of the new cements were studied and compared with pure brushite cement. The results indicated that the injectability, setting time and short-and long-term mechanical strength of the material are higher than those of pure brushite cement, and the compressive strength of the TCP/MCPM/C 3 S composite paste increased with increasing aging time. Moreover, the TCP/MCPM/C 3 S specimens showed significantly improved in vitro bioactivity in simulated body fluid and similar degradability in phosphate-buffered saline as compared with brushite cement. Additionally, the reacted TCP/MCPM/C 3 S paste possesses the ability to stimulate osteoblast proliferation and promote osteoblastic differentiation of the bone marrow stromal cells. The results indicated that the TCP/MCPM/C 3 S cements may be used as a bioactive material for bone regeneration, and might have significant clinical advantage over the traditional b-TCP/MCPM brushite cement.