𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Release of gentamicin from a tricalcium phosphate bone implant

✍ Scribed by Lance D. Silverman; Lyudmila Lukashova; Oren T. Herman; Joseph M. Lane; Adele L. Boskey

Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
248 KB
Volume
25
Category
Article
ISSN
0736-0266

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The impregnation and elution of gentamicin antibiotic from a commercially available porous β‐tricalcium phosphate (TCP) bone implant material (Vitoss®, Orthovita, Inc.) was investigated in vitro. Sustained local antibiotic release is an attractive method for the prevention of infection following surgery. The purpose of this study was to evaluate the use of the naturally forming clot that occurs within a porous tissue scaffold when combined with autologous blood or bone marrow aspirate (BMA) as a method for achieving controlled drug delivery. The diffusion of antibiotic from porous TCP scaffolds was studied using water, clotted blood, or BMA as impregnating fluids. Incorporation of the drug into the porous scaffold using clotted blood or BMA as a binder produced slowed release relative to aqueous impregnated and dried samples. Modifications were made to the elution method to simulate restricted diffusion due to surrounding clotted blood, tissue, or bone that would occur in vivo. These modified methods simulated release in a surgical site and showed long release profiles, with significant amounts of antibiotic being released for up to 2 weeks. We concluded that adding gentamicin with autologous BMA is a promising method of controlling drug release. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:23–29, 2007

📜 SIMILAR VOLUMES

Adsorption and release of insulin-like g
Adsorption and release of insulin-like growth factor-I on porous tricalcium phosphate implant
✍ Laffargue, Philippe ;Fialdes, Patrice ;Frayssinet, Patrick ;Rtaimate, Mohamed ;H 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB 👁 2 views

In order to develop bone substitutes, the design of biomaterials like calcium phosphate ceramic loaded with bone growth factor are of great interest. However, it is necessary to control the amount of growth factor adsorbed onto ceramics and the kinetics of its release. Radiolabeling of insulin-like

Controlled release of tetracycline from
Controlled release of tetracycline from biodegradable β-tricalcium phosphate composites
✍ Vera Luginbuehl; Kurt Ruffieux; Claudia Hess; Dennis Reichardt; Brigitte von Rec 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 627 KB

## Abstract For use in the prevention of bone infections, a novel controlled release system composed of β‐tricalcium phosphate (TCP) granules with biodegradable coatings incorporating the antibiotic drug tetracycline (TC) was developed. Six formulations using poly(D,L‐lactide) and poly(D,L‐lactide‐

Release of gentamicin from bone regenera
Release of gentamicin from bone regenerative materials: An in vitro study
✍ M. Teller; U. Gopp; H.-G. Neumann; K.-D. Kühn 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 454 KB 👁 2 views

## Abstract Antibiotic loading of bone regenerative materials is a promising way to protect augmentation procedures from infection during the resorption phase of bone substitutes. Especially in the early stage of implantation, it should protect the grafted site against microbiological pathogens. Th

Bone formation and bioresorption after i
Bone formation and bioresorption after implantation of injectable ?-tricalcium phosphate granules-hyaluronate complex in rabbit bone defects
✍ Chazono, Masaaki ;Tanaka, Takaaki ;Komaki, Hirokazu ;Fujii, Katsuyuki 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB

## Abstract The objective of this study was to evaluate the effects of a complex of β‐tricalcium phosphate (β‐TCP) granules and 3.5% hyaluronate (β‐TCP granules–HY complex) compared with a β‐TCP block, in terms of osteoconductivity and biodegradability, to determine whether this complex would be a

Effects of alendronate on bone formation
Effects of alendronate on bone formation and osteoclastic resorption after implantation of beta-tricalcium phosphate
✍ Takaaki Tanaka; Mitsuru Saito; Masaaki Chazono; Yoshio Kumagae; Takahiro Kikuchi 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 616 KB

## Abstract The aim of this study was to determine the effects of alendronate (ALN) on osteoclastic resorption of β‐tricalcium phosphate (β‐TCP) and bone formation. β‐TCP blocks of 75% porosity, with or without ALN treatment, were implanted into cavities drilled in rabbit femoral condyles. New bone