Bombesin (BBS) and its mammalian equivalent, gastrin-releasing peptide (GRP), exhibit diverse biological functions, including that of a neurotransmitter, a regulator of gastrointestinal hormone release, and a trophic factor for various normal and neoplastic tissues. Bombesin stimulates the growth of
Bombesin stimulates growth of human prostatic cancer cells in vitro
β Scribed by Mauro Bologna; Claudio Festuccia; Paola Muzi; Leda Biordi; Marina Ciomei
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 614 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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Bombesin is a potent inducer of signal trasduction pathways involved in the proliferation and invasion of androgeninsensitive prostatic tumor cells. This study examines the bombesin-mediated modulation of pericellular proteolysis, monitoring cell capability to migrate and invade basement membranes,
Bombesin is trophic to normal pancreas and acinar cell adenocarcinoma, but its effects on d u d cell tumors are undetermined. The autocrine growth effects of bombesin on well-differentiated (HPAF, CDI I) and poorly differentiated (CD18, PANC-I) human d u d pancreatic cancer cell lines were investiga
## Abstract We developed a powerful cytotoxic analogue of bombesin ANβ215, in which the bombesin (BN)βlike carrier peptide is conjugated to 2βpyrrolino doxorubicin (ANβ201). Human prostate cancers express high levels of receptors for BN/gastrin releasing peptide (GRP) that can be used for targeted
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional polypeptide which acts as mitogen, motogen, or morphogen. In this study, we examined the effect of HGF/SF on human hair growth using organ and cell culture systems. HGF/SF was found to stimulate hair length and DNA synthesis in ha
## Background: The objective of this study was to characterize the calcium mobilizing activity of bombesin-related neuropeptides in pc-3 cells. ## Methods: Intracellular free ca2+ concentration ([ca2+]i) was measured following the administration of bombesin-related neuropeptides using spectrofluo