Biotransformations of organosilicon compounds: enantioselective reduction of acyl silanes by means of baker's yeast
✍ Scribed by Paolo Zani
- Book ID
- 114395450
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 97 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1381-1177
No coin nor oath required. For personal study only.
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## Abstract Bioreduction of 3‐substituted‐2‐oxoal‐kanephosphonates by baker's yeast afforded 3‐substituted‐2‐hydroxy‐alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically acti
## Abstract Dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (**__1__**), upon yeast‐mediated bioreduction, afforded chiral dialkyl 4‐(dialkoxyphosphoryl)‐3‐hydroxybutanoates (**__2__**) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4‐(d