Biotransformations have developed into an important tool of organic synthesis. Most synthetic sequences will benefit from the use of a biotransformation step, and the use of multiple enzyme single pot reactions enables several steps to be telescoped together.
Volumes 8a and b provide a comprehensive guide to the established and emerging uses of enzymes. Each chapter is devoted to a single class of transformation so that the competing possibilities can be readily compared, and there is a strong emphasis on practical and reliable reactions.
Topics included in Volume 8a are: Perspectives/ Practical Aspects/ Lipases/ Esterases/ Cleavage of Amide Bonds/ Nitriles/ Alkaloids/ Yeast/ Alcohol Dehydrogenases/ Hydroxylation and Dihydroxylation/ Flavin Monooxygenases
Major topics of Volume 8b: Phosphorylation/ C-C Bond Formation/ Formation of Glycoside Bonds/ Synthetic Applications
Content:
Chapter 1 Perspectives in Biotransformations (pages 5β23): Michael K. Turner
Chapter 2 Biotransformations?Practical Aspects (pages 25β34): David R. Kelly
Chapter 3 Biotransformations with Lipases (pages 36β191): Romas J. Kazlauskas and Uwe T. Bornscheuer
Chapter 4 Esterases (pages 193β241): Sara J. Phythian
Chapter 5 Cleavage and Formation of Amide Bonds (pages 243β275): David W. T. Hoople
Chapter 6 Nitriles (pages 277β324): Alan William Bunch
Chapter 7 Alkaloids (pages 326β361): Neil C. Bruce
Chapter 8 Yeast (pages 363β389): Stefano Servi
Chapter 9 Dehydrogenases?Characteristics, Design of Reaction Conditions, and Applications (pages 391β473): Jorg Peters
Chapter 10 Hydroxylation and Dihydroxylation (pages 475β533): Herbert L. Holland
Chapter 11 Flavin MonooxygenasesβUses as Catalysts for Baeyer?Villiger Ring Expansion and Heteroatom Oxidation (pages 535β587): David R. Kelly, Peter W. H. Wan and Jenny Tang