Biosynthesis of Polyketides and Related Compounds
โ Scribed by Birch, A. J.
- Book ID
- 121178454
- Publisher
- American Association for the Advancement of Science
- Year
- 1967
- Tongue
- English
- Weight
- 682 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0036-8075
No coin nor oath required. For personal study only.
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AImtract.--Tricbothecolone biosynthesized in the presence of doubly labeled mevalonate, [4(R)+'H,Z-'\*C]MVA, was degraded to show that the carbon atom at position 8 originated from C,,, of mevalonic acid. Two minor cytotoxic metabolites were isolated from 7Ikhothecium roseum and their biogenetic rel
Modular polyketide synthases that produce many clinically important natural products such as erythromycins and lovastatins have been engineered in many ways to produce novel natural products. The structural variations have included alterations to the substituents on the macrolide ring, including the