Biosynthesis of trichothecin and related compounds

✍ Scribed by Y. Machida; S. Nozoe

• Publisher: Elsevier Science
• Year: 1972
• Tongue: French
• Weight: 364 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)88930-4

✦ Synopsis

AImtract.--Tricbothecolone biosynthesized in the presence of doubly labeled mevalonate, [4(R)+'H,Z-'*C]MVA, was degraded to show that the carbon atom at position 8 originated from C,,, of mevalonic acid. Two minor cytotoxic metabolites were isolated from 7Ikhothecium roseum and their biogenetic relation to trichothecin is shown.