Biology-Oriented Combined Solid- and Solution-Phase Synthesis of a Macroline-Like Compound Collection
✍ Scribed by Wolfram Wilk; Andrea Nören-Müller; Markus Kaiser; Herbert Waldmann
- Book ID
- 102794505
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 541 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0947-6539
No coin nor oath required. For personal study only.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Preparation of a demonstration library of a,a-disubstituted-a-acylaminoketones, of interest as ecdysone agonists, is described. The five-step synthetic sequence employed a,a-disubstituted amino acids, Grignard reagents and carboxylic acids as building blocks in a strategic combination of solid phase
A solid-phase traceless synthesis of quinazolin-4-ones is described. An aldehyde functionalized resin was reductively aminated with primary amines, and the resin-bound secondary amine acylated with o-nitro-benzoic acids. The nitro group was reduced with tin(II) chloride, and the aniline acylated wit