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Biological Evaluation of Chalcones and Analogues as Hypolipidemic Agents

✍ Scribed by Lorena Santos; Rozangela Curi Pedrosa; Rogério Correa; Valdir Cechinel Filho; Ricardo José Nunes; Rosendo Augusto Yunes

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
375 KB
Volume
339
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

In order to evaluate the anti‐hyperlipidemic effect of synthetic chalcones and some analogues, nineteen compounds with different substituents in both rings were synthesized and hypolipidemic activities were measured in vivo using Triton WR1339 acute and hypercaloric chronic assays. 4′,4‐dichlorochalcone, 3′,4′,4‐trichlorochalcone, and 4′‐chlorochalcone gave an excellent decrease in serum total cholesterol and triglycerides in the acute assay. These compounds also showed significant anti‐lipidemic activity in the chronic assay.

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