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Biodistribution and pharmacokinetics of colon-specific HPMA copolymer–9-aminocamptothecin conjugate in mice

✍ Scribed by Song-Qi Gao; Zheng-Rong Lu; Pavla Kopečková; Jindřich Kopeček


Book ID
113691433
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
326 KB
Volume
117
Category
Article
ISSN
0168-3659

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## Abstract The antitumor activity of a colon‐specific __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer – 9‐aminocamptothecin (9‐AC) conjugate (P‐9‐AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P‐9‐AC treatment of mice bearing orthotopic colon tumors, w