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Biorecognizable HPMA copolymer–drug conjugates for colon-specific delivery of 9-aminocamptothecin

✍ Scribed by Shinji Sakuma; Zheng-Rong Lu; Pavla Kopečková; Jindřich Kopeček

Book ID
114161349
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
260 KB
Volume
75
Category
Article
ISSN
0168-3659

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✍ Song-Qi Gao; Yongen Sun; Pavla Kopečková; C. Matthew Peterson; Jindřich Kopeček 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

## Abstract The antitumor activity of a colon‐specific __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer – 9‐aminocamptothecin (9‐AC) conjugate (P‐9‐AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P‐9‐AC treatment of mice bearing orthotopic colon tumors, w