Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer–9-AC Conjugate in Rats

Antitumor Efficacy of Colon-Specific HPM

Antitumor Efficacy of Colon-Specific HPMA Copolymer/9-Aminocamptothecin Conjugates in Mice Bearing Human-Colon Carcinoma Xenografts

✍ Song-Qi Gao; Yongen Sun; Pavla Kopečková; C. Matthew Peterson; Jindřich Kopeček 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

## Abstract The antitumor activity of a colon‐specific __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer – 9‐aminocamptothecin (9‐AC) conjugate (P‐9‐AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P‐9‐AC treatment of mice bearing orthotopic colon tumors, w