𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Binding of oestradiol to blood proteins and aetiology of breast cancer

✍ Scribed by J. W. Moore; G. M. G. Clark; S. A. Hoare; R. R. Millis; J. L. Hayward; M. K. Quinlan; D. Y. Wang; R. D. Bulbrook

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
551 KB
Volume
38
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non-protein-bound and albumin-bound fractions (the bio-available fraction) and a lower proportion in the sex-hormone-bound fraction. The increased proportion of bio-available oestradiol was partly due to a lower concentration of sex-horrnone-binding globulin. Weight was excluded as a confounding factor. 'To whom requests for reprints should be sent.

πŸ“œ SIMILAR VOLUMES

UICC multidisciplinary project on breast
UICC multidisciplinary project on breast cancer: The epidemiology, aetiology and prevention of breast cancer
✍ A. B. Miller; R. D. Bulbrook πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 French βš– 532 KB

Breast cancer is hormonally mediated and oestrogens are the prime agents in tumour expression. This was the main conclusion of the meeting in June, 1980, of the Multidisciplinary Project on Breast Cancer of the International Union Against Cancer (Miller and Bulbrook, 1980). The present report conce

A unifying concept of the aetiology of b
A unifying concept of the aetiology of breast cancer
✍ F. de Waard; D. Trichopoulos πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 495 KB

A number of risk factors for breast cancer are considered jointly in one pathogenetic framework which relates to the formation of pre-cancerous lesions. Energy-rich diet during puberty and adolescence enhances the occurrence of pre-cancerous lesions in the breast. This process is counteracted by ful

Binding of fluvastatin to blood cells an
Binding of fluvastatin to blood cells and plasma proteins
✍ Francis L. S. Tse; David F. Nickerson; William S. Yardley πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 587 KB

The binding of fluvastatin, an inhibitor of hydroxymethylglutaryl coenzyme A reductase, to plasma proteins and red blood cells of rat, dog, and human in vitro was determined by ultrafiltration. Additionally, the stereospecificity of fluvastatin binding to proteins and the potential interaction betwe

Serum concentrations of total and non-pr
Serum concentrations of total and non-protein-bound oestradiol in patients with breast cancer and in normal controls
✍ J. W. Moore; G. M. G. Clark; R. D. Bulbrook; J. L. Hayward; J. T. Murai; G. L. H πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 French βš– 444 KB

In premenopausal women with breast cancer. total serum oestradiol (Ed concentrations are normal but nonprotein-bound E, concentrations are significantly raised. This is not due to low sex-hormone-binding-globulin (SHBG) binding capacities which are within the normal range and is unlikely to be due t

The distribution of oestradiol in plasma
The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer: Relationships with metabolic clearance rates of oestradiol
✍ M. J. Reed; P. A. Beranek; R. W. Cheng; M. W. Ghilchik; V. H. T. James πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 French βš– 429 KB πŸ‘ 2 views

## Abstract The distribution of oestradiol in plasma from post‐menopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR‐E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was