Serum concentrations of total and non-protein-bound oestradiol in patients with breast cancer and in normal controls

✍ Scribed by J. W. Moore; G. M. G. Clark; R. D. Bulbrook; J. L. Hayward; J. T. Murai; G. L. Hammond; P. K. Siiteri

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: French
• Weight: 444 KB
• Volume: 29
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910290105

✦ Synopsis

In premenopausal women with breast cancer. total serum oestradiol (Ed concentrations are normal but nonprotein-bound E, concentrations are significantly raised. This is not due to low sex-hormone-binding-globulin (SHBG) binding capacities which are within the normal range and is unlikely to be due to the small but significant decrease in albumin concentrations. In post-menopausal patients, both total and non-protein-bound E, are significantly raised: this may be explained partially by lower SHBG binding capacities. In patients and controls there is a highly significant correlation between non-proteinbound E, and SHBG but, for a given SHBG binding capaciy, the patients have more non-bound E, than controls. It IS concluded that the breast in women with breast cancer may be exposed to elevated levels of biologically active E, although the reasons for this remain obscure. 'Numbers of subjects are shown in parentheses. -zTotaI and non-protein-bound E, concentrations are not normally distributed and are therefore expressed as Log,,.