Breast cancer is hormonally mediated and oestrogens are the prime agents in tumour expression. This was the main conclusion of the meeting in June, 1980, of the Multidisciplinary Project on Breast Cancer of the International Union Against Cancer (Miller and Bulbrook, 1980). The present report conce
A unifying concept of the aetiology of breast cancer
โ Scribed by F. de Waard; D. Trichopoulos
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 495 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
โฆ Synopsis
A number of risk factors for breast cancer are considered jointly in one pathogenetic framework which relates to the formation of pre-cancerous lesions. Energy-rich diet during puberty and adolescence enhances the occurrence of pre-cancerous lesions in the breast. This process is counteracted by full-term pregnancies, and the earlier they come the fewer the number of such lesions. Energy-rich diet later in life contributes to the occurrence of obesity which, after menopause, enhances the growth of existing subclinical and clinical breast cancer. In both periods of life the nutritional factor exerts its effect through endocrine mechanisms in which oestrogens play a major part.
๐ SIMILAR VOLUMES
A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non-protein-bound and albumin-bound fractions (the bio-available fraction) and a lower proportion in the sex-hormone-bound