Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio
β Scribed by Zong, Hong; Thomas, Thommey P.; Lee, Kyung-Hoon; Desai, Ankur M.; Li, Ming-hsin; Kotlyar, Alina; Zhang, Yuehua; Leroueil, Pascale R.; Gam, Jeremy J.; Banaszak Holl, Mark M.; Baker, James R.
- Book ID
- 118062330
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 475 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1525-7797
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π SIMILAR VOLUMES
## Abstract Dendrimer polyamidoamine generation fiveβfolic acid conjugate was synthesesed and radiolabelled with __fac__β[^99m^Tc(CO)~3~(H~2~O)~3~]^+^, its __in vitro__ stability was evaluated further. Both of the labeling yield and radiochemical purity of the G5βFAβDTPAβ^99m^Tc(CO)~3~ conjugate ex
To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent. FA was successfully conjugated to CS confirmed b