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Preparation, evaluation, and in vitro release of folic acid conjugated O-carboxymethyl chitosan nanoparticles loaded with methotrexate

โœ Scribed by Jingou Ji; Danjun Wu; Li Liu; Jida Chen; Yi Xu


Book ID
112001934
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
950 KB
Volume
125
Category
Article
ISSN
0021-8995

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โœ Jingou Ji; Danjun Wu; Li Liu; Jida Chen; Yi Xu ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Springer ๐ŸŒ English โš– 383 KB

To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent. FA was successfully conjugated to CS confirmed b