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Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery

โœ Scribed by Jingou Ji; Danjun Wu; Li Liu; Jida Chen; Yi Xu

Book ID
113028516
Publisher
Springer
Year
2011
Tongue
English
Weight
383 KB
Volume
68
Category
Article
ISSN
0170-0839

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Preparation, characterization, and in vi
Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery
โœ Jingou Ji; Danjun Wu; Li Liu; Jida Chen; Yi Xu ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Springer ๐ŸŒ English โš– 383 KB

To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent. FA was successfully conjugated to CS confirmed b