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Folic acid conjugated glycol chitosan micelles for targeted delivery of doxorubicin: preparation and preliminary evaluation in vitro

โœ Scribed by Yu, Jingmou; Xie, Xin; Wu, Jiazhong; Liu, Yonghua; Liu, Pinjian; Xu, Xiaoyuan; Yu, Huan; Lu, Lu; Che, Xiangxin


Book ID
120412383
Publisher
Taylor and Francis Group
Year
2012
Tongue
English
Weight
409 KB
Volume
24
Category
Article
ISSN
0920-5063

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To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent. FA was successfully conjugated to CS confirmed b