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Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors

✍ Scribed by Ornstein, Paul L.; Zimmerman, Dennis M.; Arnold, M. Brian; Bleisch, Thomas J.; Cantrell, Buddy; Simon, Richard; Zarrinmayeh, Hamideh; Baker, S. Richard; Gates, Mary; Tizzano, Joseph P.; Bleakman, David; Mandelzys, Allan; Jarvie, Kieth R.; Ho, Ken; Deverill, Michelle; Kamboj, Rajender K.


Book ID
123617346
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
64 KB
Volume
43
Category
Article
ISSN
0022-2623

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We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com